One unblocked strike from a heavyweight could maybe severely injure one of the smaller guys but I don't think that they would ever be able to get a state athletic commission to approve such a bout. I have a feeling that it is going to most likely remain around the welter/ middleweight division and that people will be called out one class above or below to contest for it. Keep in mind there are only around 15 lbs between these classes and while that sounds like a year-long adventure for someone like you and me to drop that sort of weight, it isn't that big of a deal for two fighters to "meet in the middle" ... I'm not gonna say that fighters do it all the time, but we do see people like Conor McGregor winning the belts in two different weight classes.
The idea that someone that weighs 260lbs would ever fight someone who weighs 140 would be ludicrous. He could kill the guy. I mean what would the featherweight guy's strategy be? Run away? If big boy catches them they would be done for.